Centrosome biology and human disease

We study how the centrosome regulates cell function and influences development. Our research focuses on how the pericentriolar material (PCM) is organized and how it contributes to centrosome maturation and ciliary function. We also investigate how centrosomal dysfunction at the cellular level is translated into developmental anomaly at the organismal level. Using a combination of approaches encompassing proteomics, cell biology, advanced microscopy, and zebrafish genetics, we aim to dissect the basic biology of centrosome organization and to bridge the knowledge gap between centrosome dysfunction and disease phenotypes.